Drug interactions
Cholecalciferol + Digoxin
Severity: Major
Cholecalciferol and Digoxin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D-induced hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. The risk is greatest with high-dose vitamin D or active analogs.
What this interaction means in plain words
Cholecalciferol and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholecalciferol belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
Why it happens
Hypercalcemia augments digoxin's cardiac effects, increasing digoxin toxicity risk.
What to do
Monitor serum calcium and digoxin toxicity signs, and keep vitamin D doses modest; adjust therapy if calcium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cholecalciferol
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
- Calcium gluconate + Cholecalciferol Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Cholecalciferol with Digoxin?
MediHelp rates the interaction as major. Cholecalciferol and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin D-induced hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. The risk is greatest with high-dose vitamin D or active analogs.
How serious is the interaction between Cholecalciferol and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and digoxin toxicity signs, and keep vitamin D doses modest; adjust therapy if calcium rises.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium Carbonate. The full list is on the Cholecalciferol page.
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