Drug interactions
clarithromycin + digoxin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ digoxin levels/toxicity.
Mechanism of action
P-gp inhibition; microbiome effects.
Clinical management
Avoid or monitor digoxin levels closely.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with digoxin?
The interaction is rated: Major. ↑ digoxin levels/toxicity.
How serious is the interaction between clarithromycin and digoxin?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between clarithromycin and digoxin managed?
Avoid or monitor digoxin levels closely.
Why do clarithromycin and digoxin interact?
P-gp inhibition; microbiome effects.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.