Drug interactions
Digoxin + Dronedarone
Severity: Major
Digoxin and Dronedarone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone raises digoxin concentrations, roughly doubling exposure in studies, and both drugs slow AV conduction. This increases the risk of digoxin toxicity, bradycardia and heart block.
What this interaction means in plain words
Digoxin and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein-mediated digoxin efflux, plus additive effects on sinus and AV node conduction.
What to do
Reduce the digoxin dose by about half or stop it, and monitor digoxin levels, heart rate and ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Digoxin with Dronedarone?
MediHelp rates the interaction as major. Digoxin and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone raises digoxin concentrations, roughly doubling exposure in studies, and both drugs slow AV conduction. This increases the risk of digoxin toxicity, bradycardia and heart block.
How serious is the interaction between Digoxin and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the digoxin dose by about half or stop it, and monitor digoxin levels, heart rate and ECG closely.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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