Drug interactions
dofetilide + ketoconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ dofetilide exposure with QT prolongation.
Mechanism of action
Strong CYP3A4 inhibition and transport effects.
Clinical management
Avoid per label.
Drug reference
References
- Dofetilide – Label — FDA Label
- Azoles with Class III antiarrhythmics — PubMed
Frequently asked questions
Can I take dofetilide with ketoconazole?
The interaction is rated: Contraindicated. ↑ dofetilide exposure with QT prolongation.
How serious is the interaction between dofetilide and ketoconazole?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dofetilide and ketoconazole managed?
Avoid per label.
Why do dofetilide and ketoconazole interact?
Strong CYP3A4 inhibition and transport effects.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.