Drug interactions
Disopyramide + Ketoconazole
Severity: Contraindicated
Disopyramide and Ketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases disopyramide levels and both drugs prolong the QT interval. This raises the risk of torsades de pointes and other ventricular arrhythmias.
What this interaction means in plain words
Disopyramide and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by ketoconazole raises disopyramide exposure, combined with additive QT prolongation.
What to do
Avoid the combination. Use an antifungal with less QT and CYP3A4 effect, or an alternative antiarrhythmic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Disopyramide with Ketoconazole?
MediHelp rates the interaction as contraindicated. Disopyramide and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole increases disopyramide levels and both drugs prolong the QT interval. This raises the risk of torsades de pointes and other ventricular arrhythmias.
How serious is the interaction between Disopyramide and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an antifungal with less QT and CYP3A4 effect, or an alternative antiarrhythmic.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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