Drug interactions
Methamphetamine + Midodrine
Severity: Major
Methamphetamine and Midodrine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is an indirect sympathomimetic and midodrine is an alpha-1 agonist vasopressor, so together they can produce additive pressor effects. This may cause marked hypertension, reflex bradycardia, palpitations or arrhythmia, and the risk is higher in patients with cardiovascular disease.
What this interaction means in plain words
Methamphetamine and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methamphetamine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic vasoconstrictor and sympathomimetic effects at adrenergic receptors.
What to do
Avoid the combination when possible; if it is unavoidable, monitor blood pressure and heart rate frequently, including supine readings. Lower or hold midodrine if blood pressure becomes excessive.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Methamphetamine with Midodrine?
MediHelp rates the interaction as major. Methamphetamine and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methamphetamine is an indirect sympathomimetic and midodrine is an alpha-1 agonist vasopressor, so together they can produce additive pressor effects. This may cause marked hypertension, reflex bradycardia, palpitations or arrhythmia, and the risk is higher in patients with cardiovascular disease.
How serious is the interaction between Methamphetamine and Midodrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if it is unavoidable, monitor blood pressure and heart rate frequently, including supine readings. Lower or hold midodrine if blood pressure becomes excessive.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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