Drug interactions
Ensitrelvir + Quinidine
Severity: Contraindicated
Ensitrelvir and Quinidine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ensitrelvir inhibits CYP3A and can raise quinidine concentrations. Elevated quinidine increases the risk of QT prolongation and serious ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Ensitrelvir and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Quinidine belongs to Anti Parasitic.
Why it happens
Ensitrelvir inhibits CYP3A, reducing quinidine metabolism.
What to do
Do not combine; use an alternative COVID-19 therapy or antiarrhythmic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ensitrelvir and Quinidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Ensitrelvir with Quinidine?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ensitrelvir inhibits CYP3A and can raise quinidine concentrations. Elevated quinidine increases the risk of QT prolongation and serious ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Ensitrelvir and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative COVID-19 therapy or antiarrhythmic.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
