Drug interactions
Eliglustat + Quinidine
Severity: Contraindicated
Eliglustat and Quinidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a strong CYP2D6 inhibitor and also inhibits P-gp, and eliglustat is cleared mainly by CYP2D6 and CYP3A. Eliglustat levels can rise substantially, and since both drugs affect cardiac conduction, PR, QTc and QRS prolongation and arrhythmia become a concern.
What this interaction means in plain words
Eliglustat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibition of CYP2D6 (and P-gp) increases eliglustat exposure, with additive effects on cardiac conduction.
What to do
Avoid the combination; use another class I antiarrhythmic only with specialist advice and ECG monitoring, or choose an alternative therapy for Gaucher disease.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Quinidine?
MediHelp rates the interaction as contraindicated. Eliglustat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Quinidine is a strong CYP2D6 inhibitor and also inhibits P-gp, and eliglustat is cleared mainly by CYP2D6 and CYP3A. Eliglustat levels can rise substantially, and since both drugs affect cardiac conduction, PR, QTc and QRS prolongation and arrhythmia become a concern.
How serious is the interaction between Eliglustat and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use another class I antiarrhythmic only with specialist advice and ECG monitoring, or choose an alternative therapy for Gaucher disease.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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