Drug interactions
Simvastatin + Voriconazole
Severity: Contraindicated
Simvastatin and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole markedly increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Simvastatin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Simvastatin belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole strongly inhibits CYP3A4, the main route of simvastatin metabolism.
What to do
Avoid the combination; use a statin not dependent on CYP3A4 such as rosuvastatin or pravastatin, or suspend simvastatin during voriconazole therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Simvastatin with Voriconazole?
MediHelp rates the interaction as contraindicated. Simvastatin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole markedly increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Simvastatin and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a statin not dependent on CYP3A4 such as rosuvastatin or pravastatin, or suspend simvastatin during voriconazole therapy.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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