Drug interactions
Atazanavir + Zileuton
Severity: Moderate
Atazanavir and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is partly metabolized by CYP3A4, so atazanavir may raise zileuton concentrations. Zileuton also inhibits CYP3A4 and may affect atazanavir exposure to a lesser degree, so the clinical effect is uncertain. Higher zileuton exposure may increase adverse effects, including liver enzyme elevations.
What this interaction means in plain words
Atazanavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Zileuton belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of zileuton by atazanavir.
What to do
Monitor liver enzymes at baseline and periodically during combined use and watch for adverse effects. Reduce or stop zileuton if ALT rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Zileuton?
MediHelp rates the interaction as moderate. Atazanavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton is partly metabolized by CYP3A4, so atazanavir may raise zileuton concentrations. Zileuton also inhibits CYP3A4 and may affect atazanavir exposure to a lesser degree, so the clinical effect is uncertain. Higher zileuton exposure may increase adverse effects, including liver enzyme elevations.
How serious is the interaction between Atazanavir and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes at baseline and periodically during combined use and watch for adverse effects. Reduce or stop zileuton if ALT rises significantly.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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