Drug interactions
Aluminum hydroxide + Crizotinib
Severity: Minor
Aluminum hydroxide and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib solubility falls as pH rises, so antacids could theoretically reduce its absorption. No formal clinical study confirms a meaningful loss of effect.
What this interaction means in plain words
Aluminum hydroxide and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Crizotinib belongs to Oncology.
Why it happens
Increased gastric pH may reduce crizotinib solubility and thereby its absorption; this is theoretical.
What to do
Separating the antacid from crizotinib by a couple of hours is a reasonable precaution. Monitor tumor response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aluminum hydroxide
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Aluminum hydroxide with Crizotinib?
MediHelp rates the interaction as minor. Aluminum hydroxide and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib solubility falls as pH rises, so antacids could theoretically reduce its absorption. No formal clinical study confirms a meaningful loss of effect.
How serious is the interaction between Aluminum hydroxide and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separating the antacid from crizotinib by a couple of hours is a reasonable precaution. Monitor tumor response and tolerability.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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