Drug interactions
Amantadine + Modafinil
Severity: Minor
Amantadine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have CNS stimulating properties, so together they may increase insomnia, agitation, anxiety or tremor. The effect is mostly additive and usually manageable.
What this interaction means in plain words
Amantadine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Modafinil belongs to Central Nervous System.
Why it happens
Additive central nervous system stimulation.
What to do
Monitor for insomnia, agitation and anxiety, and reduce a dose or give the later dose earlier in the day if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Modafinil
Frequently asked questions
Can I take Amantadine with Modafinil?
MediHelp rates the interaction as minor. Amantadine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have CNS stimulating properties, so together they may increase insomnia, agitation, anxiety or tremor. The effect is mostly additive and usually manageable.
How serious is the interaction between Amantadine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for insomnia, agitation and anxiety, and reduce a dose or give the later dose earlier in the day if symptoms occur.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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