Drug interactions
Amantadine + Tiotropium-olodaterol
Severity: Minor
Amantadine and Tiotropium-olodaterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has anticholinergic properties, so it may add to the effects of tiotropium. Systemic exposure to inhaled tiotropium is low, so the additional effect is usually small, though dry mouth or urinary retention may occur.
What this interaction means in plain words
Amantadine and Tiotropium-olodaterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic antagonism, limited by low systemic tiotropium exposure.
What to do
Monitor for urinary retention, constipation and dry mouth, particularly in older patients or those with prostatic enlargement or narrow-angle glaucoma.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium-olodaterol
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Tiotropium-olodaterol?
MediHelp rates the interaction as minor. Amantadine and Tiotropium-olodaterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amantadine has anticholinergic properties, so it may add to the effects of tiotropium. Systemic exposure to inhaled tiotropium is low, so the additional effect is usually small, though dry mouth or urinary retention may occur.
How serious is the interaction between Amantadine and Tiotropium-olodaterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and dry mouth, particularly in older patients or those with prostatic enlargement or narrow-angle glaucoma.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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