Drug interactions
Ambrisentan + Nicardipine
Severity: Minor
Ambrisentan and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can inhibit P-glycoprotein, and ambrisentan is a P-gp substrate, so exposure could rise slightly. Ambrisentan labeling does not describe a clinically meaningful effect from P-gp inhibitors.
What this interaction means in plain words
Ambrisentan and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Possible P-glycoprotein inhibition by nicardipine reducing ambrisentan efflux.
What to do
No dose adjustment is required. Monitor for hypotension, edema and headache when starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Nicardipine?
MediHelp rates the interaction as minor. Ambrisentan and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine can inhibit P-glycoprotein, and ambrisentan is a P-gp substrate, so exposure could rise slightly. Ambrisentan labeling does not describe a clinically meaningful effect from P-gp inhibitors.
How serious is the interaction between Ambrisentan and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for hypotension, edema and headache when starting the combination.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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