Drug interactions
Ambrisentan + Quinidine
Severity: Minor
Ambrisentan and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and may slightly raise ambrisentan exposure. Ambrisentan interactions with P-gp inhibitors such as cyclosporine have not required dose changes, so the clinical impact is likely small.
What this interaction means in plain words
Ambrisentan and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Why it happens
P-glycoprotein inhibition by quinidine may modestly reduce ambrisentan efflux.
What to do
No dose adjustment is generally needed; monitor for edema, headache and hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Quinidine?
MediHelp rates the interaction as minor. Ambrisentan and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein and may slightly raise ambrisentan exposure. Ambrisentan interactions with P-gp inhibitors such as cyclosporine have not required dose changes, so the clinical impact is likely small.
How serious is the interaction between Ambrisentan and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for edema, headache and hypotension.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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