Drug interactions
Amifampridine + Chlorpromazine
Severity: Moderate
Amifampridine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine dose-dependently lowers seizure threshold, and chlorpromazine also lowers it. Using both increases the risk of seizures.
What this interaction means in plain words
Amifampridine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects.
What to do
Use the lowest effective amifampridine dose and monitor for seizure activity. Consider a antipsychotic with lower seizure liability if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifampridine and Chlorpromazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Chlorpromazine?
MediHelp rates the interaction as moderate. Amifampridine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine dose-dependently lowers seizure threshold, and chlorpromazine also lowers it. Using both increases the risk of seizures.
How serious is the interaction between Amifampridine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective amifampridine dose and monitor for seizure activity. Consider a antipsychotic with lower seizure liability if feasible.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
