Drug interactions
Amifampridine + Prochlorperazine
Severity: Moderate
Amifampridine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine carries a dose-related risk of seizures, and phenothiazines such as prochlorperazine can lower the seizure threshold. Using them together may raise the likelihood of a seizure, particularly in patients with epilepsy or other risk factors.
What this interaction means in plain words
Amifampridine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic lowering of the seizure threshold by both drugs.
What to do
Avoid the combination in patients with a seizure history where possible, or use the lowest effective doses of both. Counsel patients and monitor for new or worsening seizure activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifampridine and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Prochlorperazine?
MediHelp rates the interaction as moderate. Amifampridine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine carries a dose-related risk of seizures, and phenothiazines such as prochlorperazine can lower the seizure threshold. Using them together may raise the likelihood of a seizure, particularly in patients with epilepsy or other risk factors.
How serious is the interaction between Amifampridine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history where possible, or use the lowest effective doses of both. Counsel patients and monitor for new or worsening seizure activity.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
