Drug interactions
Amifostine + Avanafil
Severity: Moderate
Amifostine and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and avanafil may add to this vasodilatory effect. Patients may experience symptomatic drops in blood pressure around infusions.
What this interaction means in plain words
Amifostine and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Avanafil belongs to Genitourinary.
Why it happens
Additive hypotensive effects from amifostine and PDE5 inhibition.
What to do
Avoid taking avanafil on the day of amifostine infusion and monitor blood pressure during treatment. Follow standard amifostine hydration and antihypertensive hold recommendations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Avanafil?
MediHelp rates the interaction as moderate. Amifostine and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and avanafil may add to this vasodilatory effect. Patients may experience symptomatic drops in blood pressure around infusions.
How serious is the interaction between Amifostine and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking avanafil on the day of amifostine infusion and monitor blood pressure during treatment. Follow standard amifostine hydration and antihypertensive hold recommendations.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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