Drug interactions
Amikacin + Entecavir
Severity: Minor
Amikacin and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated renally, and amikacin can reduce kidney function, which may raise entecavir exposure. Entecavir itself has little nephrotoxic potential, but accumulation of either drug is possible if renal function declines.
What this interaction means in plain words
Amikacin and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amikacin belongs to Anti Bacterial; Entecavir belongs to Anti Virals.
Why it happens
Aminoglycoside-induced reduction in renal function may decrease renal elimination of entecavir.
What to do
Monitor renal function during amikacin therapy and adjust entecavir dosing interval to creatinine clearance if function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Frequently asked questions
Can I take Amikacin with Entecavir?
MediHelp rates the interaction as minor. Amikacin and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are eliminated renally, and amikacin can reduce kidney function, which may raise entecavir exposure. Entecavir itself has little nephrotoxic potential, but accumulation of either drug is possible if renal function declines.
How serious is the interaction between Amikacin and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during amikacin therapy and adjust entecavir dosing interval to creatinine clearance if function declines.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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