Drug interactions
Amiloride + Avanafil
Severity: Minor
Amiloride and Avanafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may modestly add to the blood pressure lowering of amiloride. Clinically significant hypotension is uncommon but possible with volume depletion.
What this interaction means in plain words
Amiloride and Avanafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive hypotension from PDE5-mediated vasodilation and diuretic volume reduction.
What to do
Monitor blood pressure after starting avanafil. No dose adjustment is normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Avanafil?
MediHelp rates the interaction as minor. Amiloride and Avanafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avanafil may modestly add to the blood pressure lowering of amiloride. Clinically significant hypotension is uncommon but possible with volume depletion.
How serious is the interaction between Amiloride and Avanafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting avanafil. No dose adjustment is normally required.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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