Drug interactions
Amiloride + Disopyramide
Severity: Moderate
Amiloride and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyperkalemia caused by amiloride may increase the cardiac toxicity of antiarrhythmics such as disopyramide, with conduction slowing. Disopyramide itself may also reduce blood pressure and contractility.
What this interaction means in plain words
Amiloride and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Disopyramide belongs to Cardiovascular.
Why it happens
Potassium retention from amiloride may exaggerate the conduction-slowing effects of class I antiarrhythmics, in addition to additive cardiovascular depression.
What to do
Monitor serum potassium and ECG, and correct hyperkalemia promptly. Review blood pressure and heart rhythm after starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Amiloride with Disopyramide?
MediHelp rates the interaction as moderate. Amiloride and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyperkalemia caused by amiloride may increase the cardiac toxicity of antiarrhythmics such as disopyramide, with conduction slowing. Disopyramide itself may also reduce blood pressure and contractility.
How serious is the interaction between Amiloride and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG, and correct hyperkalemia promptly. Review blood pressure and heart rhythm after starting.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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