Drug interactions
Disopyramide + Dronedarone
Severity: Contraindicated
Disopyramide and Dronedarone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, and disopyramide has proarrhythmic and negative inotropic effects. Combined use substantially raises the risk of torsades de pointes.
What this interaction means in plain words
Disopyramide and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Do not use together; allow adequate washout when switching between class I/III agents.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Disopyramide with Dronedarone?
MediHelp rates the interaction as contraindicated. Disopyramide and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, and disopyramide has proarrhythmic and negative inotropic effects. Combined use substantially raises the risk of torsades de pointes.
How serious is the interaction between Disopyramide and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow adequate washout when switching between class I/III agents.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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