Drug interactions
Amiloride + Magnesium sulphate
Severity: Minor
Amiloride and Magnesium sulphate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride is potassium-sparing and has little magnesium-wasting effect, and it may slightly reduce urinary magnesium loss. The clinical effect on magnesium sulfate levels is small in patients with normal renal function. Caution is warranted in renal impairment, where magnesium can accumulate.
What this interaction means in plain words
Amiloride and Magnesium sulphate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Amiloride may reduce renal magnesium excretion modestly.
What to do
No routine adjustment is needed. Monitor serum magnesium and potassium when giving parenteral magnesium to patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Magnesium sulphate?
MediHelp rates the interaction as minor. Amiloride and Magnesium sulphate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride is potassium-sparing and has little magnesium-wasting effect, and it may slightly reduce urinary magnesium loss. The clinical effect on magnesium sulfate levels is small in patients with normal renal function. Caution is warranted in renal impairment, where magnesium can accumulate.
How serious is the interaction between Amiloride and Magnesium sulphate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor serum magnesium and potassium when giving parenteral magnesium to patients with renal impairment.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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