Drug interactions
Baloxavir marboxil + Magnesium sulphate
Severity: Moderate
Baloxavir marboxil and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polyvalent cations such as magnesium can chelate baloxavir in the gut and reduce its absorption, which could lower antiviral exposure and weaken influenza treatment or prophylaxis. This is mainly relevant to oral magnesium products, not parenteral magnesium sulfate.
What this interaction means in plain words
Baloxavir marboxil and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baloxavir marboxil belongs to Anti Virals; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Chelation of baloxavir by magnesium in the gastrointestinal tract reduces its oral absorption.
What to do
Avoid taking baloxavir together with oral magnesium-containing laxatives, antacids or supplements; if needed, give baloxavir at a different time and consider the product labeling advice on separation. Parenteral magnesium does not need separation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
- Delafloxacin + Magnesium sulphate Moderate
Other interactions of Baloxavir marboxil
- Aluminum hydroxide + Baloxavir marboxil Moderate
- Baloxavir marboxil + Calcium Moderate
- Baloxavir marboxil + Calcium carbonate Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Baloxavir marboxil + Ferrous fumarate Moderate
- Baloxavir marboxil + Ferrous gluconate Moderate
Frequently asked questions
Can I take Baloxavir marboxil with Magnesium sulphate?
MediHelp rates the interaction as moderate. Baloxavir marboxil and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Polyvalent cations such as magnesium can chelate baloxavir in the gut and reduce its absorption, which could lower antiviral exposure and weaken influenza treatment or prophylaxis. This is mainly relevant to oral magnesium products, not parenteral magnesium sulfate.
How serious is the interaction between Baloxavir marboxil and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking baloxavir together with oral magnesium-containing laxatives, antacids or supplements; if needed, give baloxavir at a different time and consider the product labeling advice on separation. Parenteral magnesium does not need separation.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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