Drug interactions
Cisatracurium + Magnesium sulphate
Severity: Moderate
Cisatracurium and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral magnesium sulfate enhances the effect of cisatracurium, leading to a deeper and longer neuromuscular block. Delayed recovery may prolong ventilatory support.
What this interaction means in plain words
Cisatracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Magnesium decreases presynaptic acetylcholine release and reduces postjunctional sensitivity, adding to competitive neuromuscular blockade.
What to do
Use reduced cisatracurium doses and monitor neuromuscular function with train-of-four. Anticipate prolonged recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Delafloxacin + Magnesium sulphate Moderate
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Magnesium sulphate?
MediHelp rates the interaction as moderate. Cisatracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate enhances the effect of cisatracurium, leading to a deeper and longer neuromuscular block. Delayed recovery may prolong ventilatory support.
How serious is the interaction between Cisatracurium and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced cisatracurium doses and monitor neuromuscular function with train-of-four. Anticipate prolonged recovery.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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