Drug interactions
Amphotericin b deoxycholate + Magnesium sulphate
Severity: Moderate
Amphotericin b deoxycholate and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate causes renal tubular injury with magnesium wasting, leading to hypomagnesemia. This can reduce the effect of magnesium supplementation and cause cardiac and neuromuscular problems.
What this interaction means in plain words
Amphotericin b deoxycholate and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin-induced tubular damage increases urinary magnesium excretion.
What to do
Monitor serum magnesium, potassium and renal function, and increase magnesium replacement as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
- Delafloxacin + Magnesium sulphate Moderate
Frequently asked questions
Can I take Amphotericin b deoxycholate with Magnesium sulphate?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate causes renal tubular injury with magnesium wasting, leading to hypomagnesemia. This can reduce the effect of magnesium supplementation and cause cardiac and neuromuscular problems.
How serious is the interaction between Amphotericin b deoxycholate and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and renal function, and increase magnesium replacement as required.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Atracurium, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
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