Drug interactions
Aminolevulinic acid + Glibenclamide
Severity: Moderate
Aminolevulinic acid and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminolevulinic acid used for visualization in surgery causes transient skin photosensitivity. Glyburide may rarely cause photosensitivity, so effects may be additive.
What this interaction means in plain words
Aminolevulinic acid and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Glibenclamide belongs to Endocrine.
Why it happens
Additive photosensitizing effects of protoporphyrin accumulation and sulfonylurea-related photosensitivity.
What to do
Counsel the patient to avoid sunlight and bright light for the period in the aminolevulinic acid labeling. Monitor the skin and avoid other phototoxic drugs for 24 hours around the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aminolevulinic acid and Glibenclamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Glibenclamide?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid used for visualization in surgery causes transient skin photosensitivity. Glyburide may rarely cause photosensitivity, so effects may be additive.
How serious is the interaction between Aminolevulinic acid and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid sunlight and bright light for the period in the aminolevulinic acid labeling. Monitor the skin and avoid other phototoxic drugs for 24 hours around the procedure.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
