Drug interactions
Amiodarone + Amobarbital
Severity: Moderate
Amiodarone and Amobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces hepatic enzymes including CYP3A4 and may lower amiodarone concentrations. This could reduce antiarrhythmic efficacy, and the long half-life of amiodarone makes changes gradual.
What this interaction means in plain words
Amiodarone and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Amobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 and related enzymes increasing amiodarone metabolism.
What to do
Monitor arrhythmia control and ECG, and consider amiodarone dose adjustment if efficacy declines. Prefer a non-inducing sedative if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amiodarone with Amobarbital?
MediHelp rates the interaction as moderate. Amiodarone and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces hepatic enzymes including CYP3A4 and may lower amiodarone concentrations. This could reduce antiarrhythmic efficacy, and the long half-life of amiodarone makes changes gradual.
How serious is the interaction between Amiodarone and Amobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor arrhythmia control and ECG, and consider amiodarone dose adjustment if efficacy declines. Prefer a non-inducing sedative if possible.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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