Drug interactions
Amiodarone + Atogepant
Severity: Minor
Amiodarone and Atogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is a weak to moderate CYP3A4 inhibitor and may raise atogepant exposure. Higher atogepant levels could increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Amiodarone and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Atogepant belongs to Central Nervous System.
Why it happens
Amiodarone inhibits CYP3A4-mediated metabolism of atogepant, reducing its clearance.
What to do
No routine dose change is required for a weak or moderate CYP3A4 inhibitor; monitor tolerability of atogepant. Consider dose review if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Atogepant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Amiodarone with Atogepant?
MediHelp rates the interaction as minor. Amiodarone and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone is a weak to moderate CYP3A4 inhibitor and may raise atogepant exposure. Higher atogepant levels could increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Amiodarone and Atogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required for a weak or moderate CYP3A4 inhibitor; monitor tolerability of atogepant. Consider dose review if adverse effects emerge.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
