Drug interactions
Amiodarone + Bosentan
Severity: Moderate
Amiodarone and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower amiodarone concentrations, reducing antiarrhythmic effect. Amiodarone, a CYP3A4/2C9 inhibitor, could in turn increase bosentan levels and hepatotoxicity risk.
What this interaction means in plain words
Amiodarone and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induction of CYP3A4 raises amiodarone clearance, while amiodarone inhibition may raise bosentan exposure.
What to do
Monitor heart rhythm and liver function tests regularly. Adjust the amiodarone dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Amiodarone with Bosentan?
MediHelp rates the interaction as moderate. Amiodarone and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower amiodarone concentrations, reducing antiarrhythmic effect. Amiodarone, a CYP3A4/2C9 inhibitor, could in turn increase bosentan levels and hepatotoxicity risk.
How serious is the interaction between Amiodarone and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and liver function tests regularly. Adjust the amiodarone dose according to clinical response.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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