Drug interactions
Amiodarone + Brexpiprazole
Severity: Moderate
Amiodarone and Brexpiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2D6 and CYP3A4, both of which metabolize brexpiprazole, so brexpiprazole exposure can rise. This may increase sedation, akathisia and orthostatic hypotension. Both drugs may also affect QT interval.
What this interaction means in plain words
Amiodarone and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Brexpiprazole belongs to Central Nervous System.
Why it happens
Amiodarone inhibition of CYP2D6 and CYP3A4 metabolism of brexpiprazole.
What to do
Reduce brexpiprazole to about half the usual dose with a CYP2D6 or CYP3A4 inhibitor, and to a quarter if both pathways are inhibited. Monitor ECG and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Amiodarone with Brexpiprazole?
MediHelp rates the interaction as moderate. Amiodarone and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2D6 and CYP3A4, both of which metabolize brexpiprazole, so brexpiprazole exposure can rise. This may increase sedation, akathisia and orthostatic hypotension. Both drugs may also affect QT interval.
How serious is the interaction between Amiodarone and Brexpiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce brexpiprazole to about half the usual dose with a CYP2D6 or CYP3A4 inhibitor, and to a quarter if both pathways are inhibited. Monitor ECG and adverse effects.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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