Drug interactions
Amiodarone + Darunavir
Severity: Major
Amiodarone and Darunavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise amiodarone concentrations. This increases the risk of bradycardia, QT prolongation and torsades de pointes.
What this interaction means in plain words
Amiodarone and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Darunavir belongs to Anti Virals.
Why it happens
Boosted darunavir inhibits CYP3A4, reducing amiodarone metabolism.
What to do
Monitor ECG and amiodarone concentrations closely, and lower the amiodarone dose if needed. Consider an alternative antiarrhythmic where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Amiodarone with Darunavir?
MediHelp rates the interaction as major. Amiodarone and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise amiodarone concentrations. This increases the risk of bradycardia, QT prolongation and torsades de pointes.
How serious is the interaction between Amiodarone and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and amiodarone concentrations closely, and lower the amiodarone dose if needed. Consider an alternative antiarrhythmic where possible.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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