Drug interactions
Amiodarone + Dronabinol
Severity: Minor
Amiodarone and Dronabinol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise dronabinol concentrations, potentially increasing sedation, dizziness, tachycardia and other cannabinoid effects. The evidence is mostly theoretical.
What this interaction means in plain words
Amiodarone and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Dronabinol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C9 (and CYP3A4) by amiodarone may reduce dronabinol metabolism.
What to do
Start dronabinol at a low dose and monitor for excess sedation, tachycardia or mood changes. Reduce the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Amiodarone with Dronabinol?
MediHelp rates the interaction as minor. Amiodarone and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may raise dronabinol concentrations, potentially increasing sedation, dizziness, tachycardia and other cannabinoid effects. The evidence is mostly theoretical.
How serious is the interaction between Amiodarone and Dronabinol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dronabinol at a low dose and monitor for excess sedation, tachycardia or mood changes. Reduce the dose if needed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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