Drug interactions
Amiodarone + Edoxaban
Severity: Moderate
Amiodarone and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and can raise edoxaban exposure, though the increase is modest. This may increase bleeding risk slightly.
What this interaction means in plain words
Amiodarone and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Amiodarone inhibits P-glycoprotein efflux, increasing edoxaban absorption and reducing its clearance.
What to do
Dose reduction is generally not required for atrial fibrillation; monitor for bleeding and renal function. Follow labelled dose adjustments for the indication being treated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Amiodarone with Edoxaban?
MediHelp rates the interaction as moderate. Amiodarone and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and can raise edoxaban exposure, though the increase is modest. This may increase bleeding risk slightly.
How serious is the interaction between Amiodarone and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose reduction is generally not required for atrial fibrillation; monitor for bleeding and renal function. Follow labelled dose adjustments for the indication being treated.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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