Drug interactions
Amiodarone + Eslicarbazepine
Severity: Moderate
Amiodarone and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak inducer of CYP3A4 and may lower amiodarone and its active metabolite concentrations, potentially reducing antiarrhythmic efficacy. Its inhibition of CYP2C19 is less likely to be clinically important for amiodarone.
What this interaction means in plain words
Amiodarone and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by eslicarbazepine increases amiodarone clearance, with possible minor CYP2C19 inhibition.
What to do
Monitor heart rhythm and clinical response to amiodarone when starting or stopping eslicarbazepine. Adjust the amiodarone dose if arrhythmia control is lost, guided by ECG and, where available, drug levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Amiodarone with Eslicarbazepine?
MediHelp rates the interaction as moderate. Amiodarone and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak inducer of CYP3A4 and may lower amiodarone and its active metabolite concentrations, potentially reducing antiarrhythmic efficacy. Its inhibition of CYP2C19 is less likely to be clinically important for amiodarone.
How serious is the interaction between Amiodarone and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and clinical response to amiodarone when starting or stopping eslicarbazepine. Adjust the amiodarone dose if arrhythmia control is lost, guided by ECG and, where available, drug levels.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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