Drug interactions
Amiodarone + Haloperidol
Severity: Major
Amiodarone and Haloperidol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and haloperidol carries a recognized risk of torsades de pointes, particularly at higher doses or intravenously. Combined use markedly increases arrhythmia risk.
What this interaction means in plain words
Amiodarone and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QT prolongation via potassium channel blockade; amiodarone may also inhibit haloperidol metabolism.
What to do
Avoid when possible, choosing an antipsychotic with lower QT risk. If used together, use the lowest haloperidol dose, avoid IV administration and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Amiodarone with Haloperidol?
MediHelp rates the interaction as major. Amiodarone and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and haloperidol carries a recognized risk of torsades de pointes, particularly at higher doses or intravenously. Combined use markedly increases arrhythmia risk.
How serious is the interaction between Amiodarone and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid when possible, choosing an antipsychotic with lower QT risk. If used together, use the lowest haloperidol dose, avoid IV administration and monitor ECG and electrolytes.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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