Drug interactions
Amiodarone + Hydromorphone
Severity: Minor
Amiodarone and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydromorphone is metabolized mainly by glucuronidation rather than CYP2D6, so amiodarone is unlikely to change its levels meaningfully. No important interaction is expected beyond general additive effects.
What this interaction means in plain words
Amiodarone and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Hydromorphone belongs to Musculoskeletal.
Why it happens
Amiodarone inhibits CYP2D6, which plays little role in hydromorphone clearance.
What to do
No dose adjustment is needed. Monitor for the usual opioid effects such as sedation and bradycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Hydromorphone?
MediHelp rates the interaction as minor. Amiodarone and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydromorphone is metabolized mainly by glucuronidation rather than CYP2D6, so amiodarone is unlikely to change its levels meaningfully. No important interaction is expected beyond general additive effects.
How serious is the interaction between Amiodarone and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for the usual opioid effects such as sedation and bradycardia.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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