Drug interactions
Amiodarone + Itraconazole
Severity: Major
Amiodarone and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise amiodarone levels through CYP3A4 inhibition, and both drugs prolong the QT interval. This increases the risk of torsades de pointes and other serious arrhythmias.
What this interaction means in plain words
Amiodarone and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition reducing amiodarone metabolism.
What to do
Avoid if possible and use an alternative antifungal. If coadministered, monitor ECG, electrolytes and signs of amiodarone toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Itraconazole?
MediHelp rates the interaction as major. Amiodarone and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can raise amiodarone levels through CYP3A4 inhibition, and both drugs prolong the QT interval. This increases the risk of torsades de pointes and other serious arrhythmias.
How serious is the interaction between Amiodarone and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative antifungal. If coadministered, monitor ECG, electrolytes and signs of amiodarone toxicity.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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