Drug interactions
Amiodarone + Ivacaftor
Severity: Moderate
Amiodarone and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is a weak CYP3A4 inhibitor and may modestly raise ivacaftor exposure, while ivacaftor inhibits P-glycoprotein and may raise amiodarone levels. Clinical effects are expected to be modest but amiodarone has a narrow therapeutic window.
What this interaction means in plain words
Amiodarone and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Ivacaftor belongs to Miscellaneous.
Why it happens
Amiodarone inhibits CYP3A4 metabolism of ivacaftor, and ivacaftor inhibits P-glycoprotein efflux of amiodarone.
What to do
Monitor ECG and heart rate for amiodarone excess, and watch for ivacaftor adverse effects such as elevated transaminases. Reduce amiodarone dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Amiodarone with Ivacaftor?
MediHelp rates the interaction as moderate. Amiodarone and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone is a weak CYP3A4 inhibitor and may modestly raise ivacaftor exposure, while ivacaftor inhibits P-glycoprotein and may raise amiodarone levels. Clinical effects are expected to be modest but amiodarone has a narrow therapeutic window.
How serious is the interaction between Amiodarone and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate for amiodarone excess, and watch for ivacaftor adverse effects such as elevated transaminases. Reduce amiodarone dose if toxicity develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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