Drug interactions
Amiodarone + Liposomal doxorubicin
Severity: Moderate
Amiodarone and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and could modestly raise doxorubicin exposure. Liposomal encapsulation reduces dependence on this transporter, so the effect is uncertain. Both drugs can affect the heart, with cardiomyopathy from doxorubicin and conduction effects from amiodarone.
What this interaction means in plain words
Amiodarone and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Liposomal doxorubicin belongs to Oncology.
Why it happens
Amiodarone inhibits P-glycoprotein, possibly reducing doxorubicin efflux, with additive cardiac effects.
What to do
Monitor ECG, left ventricular function and blood counts. Consider an alternative antiarrhythmic if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Amiodarone and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and could modestly raise doxorubicin exposure. Liposomal encapsulation reduces dependence on this transporter, so the effect is uncertain. Both drugs can affect the heart, with cardiomyopathy from doxorubicin and conduction effects from amiodarone.
How serious is the interaction between Amiodarone and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, left ventricular function and blood counts. Consider an alternative antiarrhythmic if clinically appropriate.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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