Drug interactions
Amiodarone + Lomitapide
Severity: Major
Amiodarone and Lomitapide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is highly dependent on CYP3A4, and amiodarone is a weak to moderate inhibitor that can raise lomitapide exposure. This raises the risk of hepatotoxicity and gastrointestinal adverse effects. Amiodarone itself can also cause liver injury.
What this interaction means in plain words
Amiodarone and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Amiodarone inhibits CYP3A4, reducing lomitapide clearance, with additive hepatotoxic potential.
What to do
Monitor liver enzymes closely and reduce the lomitapide dose per labeling for weak inhibitors. Consider an alternative to amiodarone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amiodarone with Lomitapide?
MediHelp rates the interaction as major. Amiodarone and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomitapide is highly dependent on CYP3A4, and amiodarone is a weak to moderate inhibitor that can raise lomitapide exposure. This raises the risk of hepatotoxicity and gastrointestinal adverse effects. Amiodarone itself can also cause liver injury.
How serious is the interaction between Amiodarone and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and reduce the lomitapide dose per labeling for weak inhibitors. Consider an alternative to amiodarone.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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