Drug interactions
Amiodarone + Lonafarnib
Severity: Major
Amiodarone and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate and its exposure rises with CYP3A inhibitors. Amiodarone is a weak to moderate CYP3A inhibitor and also prolongs the QT interval, as can lonafarnib.
What this interaction means in plain words
Amiodarone and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
Amiodarone inhibits CYP3A4, reducing lonafarnib metabolism, with additive QT effects.
What to do
Avoid if possible. If used, monitor ECG and lonafarnib adverse effects, and reduce the lonafarnib dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amiodarone with Lonafarnib?
MediHelp rates the interaction as major. Amiodarone and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A4 substrate and its exposure rises with CYP3A inhibitors. Amiodarone is a weak to moderate CYP3A inhibitor and also prolongs the QT interval, as can lonafarnib.
How serious is the interaction between Amiodarone and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, monitor ECG and lonafarnib adverse effects, and reduce the lonafarnib dose per labeling.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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