Drug interactions
Amiodarone + Losartan
Severity: Minor
Amiodarone and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP2C9 and CYP3A4, reducing the conversion of losartan to its more potent active metabolite E-3174. This could modestly reduce antihypertensive effect, though the clinical importance is not well established.
What this interaction means in plain words
Amiodarone and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9 and CYP3A4 by amiodarone reduces formation of the active carboxylic acid metabolite of losartan.
What to do
Monitor blood pressure after amiodarone is started or stopped and adjust the losartan dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Losartan?
MediHelp rates the interaction as minor. Amiodarone and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may inhibit CYP2C9 and CYP3A4, reducing the conversion of losartan to its more potent active metabolite E-3174. This could modestly reduce antihypertensive effect, though the clinical importance is not well established.
How serious is the interaction between Amiodarone and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after amiodarone is started or stopped and adjust the losartan dose to response.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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