Drug interactions
Amiodarone + Memantine
Severity: Minor
Amiodarone and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The proposed interaction is competition for renal tubular secretion, but amiodarone is eliminated mainly by hepatic metabolism and is not a recognized renal cation secretion inhibitor. A clinically meaningful rise in memantine is not established.
What this interaction means in plain words
Amiodarone and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Theoretical competition for renal cationic transport; not well established.
What to do
No dose change is needed; watch for memantine adverse effects such as dizziness, confusion or agitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Amiodarone with Memantine?
MediHelp rates the interaction as minor. Amiodarone and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The proposed interaction is competition for renal tubular secretion, but amiodarone is eliminated mainly by hepatic metabolism and is not a recognized renal cation secretion inhibitor. A clinically meaningful rise in memantine is not established.
How serious is the interaction between Amiodarone and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; watch for memantine adverse effects such as dizziness, confusion or agitation.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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