Drug interactions
Amiodarone + Piroxicam
Severity: Minor
Amiodarone and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9, which is the main pathway for piroxicam metabolism, so piroxicam exposure may rise. This could increase the risk of NSAID adverse effects such as gastrointestinal bleeding or renal effects.
What this interaction means in plain words
Amiodarone and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
Amiodarone inhibits CYP2C9-mediated hydroxylation of piroxicam.
What to do
No empirical dose change is needed. Use the lowest effective piroxicam dose and watch for gastrointestinal and renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Piroxicam?
MediHelp rates the interaction as minor. Amiodarone and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP2C9, which is the main pathway for piroxicam metabolism, so piroxicam exposure may rise. This could increase the risk of NSAID adverse effects such as gastrointestinal bleeding or renal effects.
How serious is the interaction between Amiodarone and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Use the lowest effective piroxicam dose and watch for gastrointestinal and renal adverse effects.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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