Drug interactions
Amiodarone + Rimegepant
Severity: Moderate
Amiodarone and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and may raise rimegepant exposure. Higher levels could increase adverse effects such as nausea and hypersensitivity reactions. The effect is likely modest but is relevant because rimegepant labeling advises against repeat dosing with P-gp inhibitors.
What this interaction means in plain words
Amiodarone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Rimegepant belongs to Central Nervous System.
Why it happens
Amiodarone inhibits P-glycoprotein efflux of rimegepant, increasing its systemic exposure.
What to do
Avoid a second rimegepant dose within 48 hours when taken with amiodarone. Monitor for adverse effects such as nausea and hypersensitivity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Amiodarone with Rimegepant?
MediHelp rates the interaction as moderate. Amiodarone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and may raise rimegepant exposure. Higher levels could increase adverse effects such as nausea and hypersensitivity reactions. The effect is likely modest but is relevant because rimegepant labeling advises against repeat dosing with P-gp inhibitors.
How serious is the interaction between Amiodarone and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with amiodarone. Monitor for adverse effects such as nausea and hypersensitivity.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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