Drug interactions
Amiodarone + Sirolimus
Severity: Moderate
Amiodarone and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase sirolimus blood concentrations, raising the risk of sirolimus adverse effects such as hyperlipidemia, cytopenias, edema and impaired wound healing. The magnitude varies between patients.
What this interaction means in plain words
Amiodarone and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Amiodarone inhibits P-glycoprotein and CYP3A4, which reduces sirolimus efflux and metabolism.
What to do
Monitor sirolimus trough concentrations when amiodarone is started, changed or stopped, and adjust the sirolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Amiodarone with Sirolimus?
MediHelp rates the interaction as moderate. Amiodarone and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase sirolimus blood concentrations, raising the risk of sirolimus adverse effects such as hyperlipidemia, cytopenias, edema and impaired wound healing. The magnitude varies between patients.
How serious is the interaction between Amiodarone and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when amiodarone is started, changed or stopped, and adjust the sirolimus dose accordingly.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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