Drug interactions
Chloramphenicol + Sonidegib
Severity: Major
Chloramphenicol and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is cleared by CYP3A4, and chloramphenicol may increase its levels. This raises the risk of musculoskeletal toxicity, including rhabdomyolysis, and other dose-related effects.
What this interaction means in plain words
Chloramphenicol and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Sonidegib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4 metabolism of sonidegib.
What to do
Avoid the combination and choose another antibiotic. If unavoidable, monitor creatine kinase and muscle symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Chloramphenicol with Sonidegib?
MediHelp rates the interaction as major. Chloramphenicol and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sonidegib is cleared by CYP3A4, and chloramphenicol may increase its levels. This raises the risk of musculoskeletal toxicity, including rhabdomyolysis, and other dose-related effects.
How serious is the interaction between Chloramphenicol and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If unavoidable, monitor creatine kinase and muscle symptoms closely.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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