Drug interactions
Amiodarone + Tazemetostat
Severity: Moderate
Amiodarone and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase tazemetostat exposure, raising the risk of its adverse effects. Amiodarone's very long half-life means the inhibition persists for weeks after stopping.
What this interaction means in plain words
Amiodarone and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Amiodarone inhibits CYP3A4, reducing tazemetostat metabolism.
What to do
Avoid if possible; if unavoidable, reduce the tazemetostat dose according to labeling for moderate CYP3A inhibitors and monitor for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Amiodarone with Tazemetostat?
MediHelp rates the interaction as moderate. Amiodarone and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase tazemetostat exposure, raising the risk of its adverse effects. Amiodarone's very long half-life means the inhibition persists for weeks after stopping.
How serious is the interaction between Amiodarone and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the tazemetostat dose according to labeling for moderate CYP3A inhibitors and monitor for toxicity.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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