Drug interactions
Amisulpride + Artemether / lumefantrine
Severity: Major
Amisulpride and Artemether / lumefantrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both artemether/lumefantrine and amisulpride can prolong the QT interval, so combined use increases the chance of torsades de pointes. The risk is greater with hypokalemia, hypomagnesemia, bradycardia or heart disease.
What this interaction means in plain words
Amisulpride and Artemether / lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Avoid if possible; otherwise obtain a baseline ECG, correct electrolytes, and monitor QTc during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Artemether / lumefantrine?
MediHelp rates the interaction as major. Amisulpride and Artemether / lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both artemether/lumefantrine and amisulpride can prolong the QT interval, so combined use increases the chance of torsades de pointes. The risk is greater with hypokalemia, hypomagnesemia, bradycardia or heart disease.
How serious is the interaction between Amisulpride and Artemether / lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline ECG, correct electrolytes, and monitor QTc during treatment.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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